

The Nasdaq Composite fell 1.5% to 25,881.95 on Thursday as a broad selloff in semiconductor stocks overshadowed better-than-expected results from Taiwan Semiconductor Manufacturing Co. "The weight of chips in the S&P 500 has grown from 8% to over 20% in the past few years," said Paul Nolte, senior wealth advisor and market strategist at Murphy & Sylvest. "If you look at the rest of the market, it's doing fine." The S&P 500 lost 0.5% to 7,533.77, while the Dow Jones Industrial Average slipped 0.2% to 52,553.32. Technology was the worst-performing S&P 500 sector, falling 1.8%, with the Philadelphia Semiconductor Index dropping 4.3%. Memory-chip makers led the decline: SanDisk tumbled 13%, Seagate Technology fell 10%, and Micron Technology lost more than 5%. U.S.-listed shares of TSMC slipped 2.3% even after the world's largest contract chipmaker posted a 77% jump in quarterly profit and raised its full-year capital expenditure forecast to as much as $64 billion. The selloff shows how elevated expectations have become for a chip sector that has surged nearly 70% this year, leaving even strong earnings vulnerable to profit-taking. With the Federal Reserve's next meeting in September and the third wave of Trump tariffs beginning next week, investors face competing narratives about the durability of the AI-driven rally. Healthcare provided the main counterweight, with the sector rising 2.2%. UnitedHealth Group gained 1.2% after reporting adjusted earnings of $6.38 per share, well above the $4.87 consensus, and lifting its full-year profit outlook to as much as $20 a share. Abbott Laboratories surged 11% to lead the S&P 500 after also beating estimates and raising guidance. Breadth data showed a mixed picture beneath the headline weakness. On the New York Stock Exchange, declining issues outnumbered advancers by a 1.08-to-1 ratio. The Nasdaq saw a wider 1.64-to-1 spread, with 2,979 stocks falling versus 1,817 rising. The S&P 500 recorded 42 new 52-week highs and just two new lows, while the Nasdaq logged 197 new highs and 155 new lows. Trading volume on U.S. exchanges totaled 17.19 billion shares, below the 21.19 billion 20-day average. The 10-year Treasury yield edged up one basis point to 4.57%, while the U.S. dollar index rose 0.3% to 100.78. Gold futures fell 1.8% to $3,980 an ounce. Oil prices declined modestly, with West Texas Intermediate crude down 0.7% to $79 a barrel, as traders assessed renewed fighting in Iran after the collapse of a short-lived ceasefire. **Earnings Season Tests High Expectations** Beyond chips, the second-quarter earnings season delivered several beats. United Airlines fell 1.8% after surging oil prices weighed on its forward guidance. GE Aerospace slid 4.1% despite lifting its 2026 profit forecast. J.B. Hunt Transport Services jumped 7% after reporting profit and revenue above analysts' estimates. S&P 500 companies are expected to post aggregate earnings growth of 24.8% from a year earlier, with technology earnings alone seen jumping 65.5%, according to LSEG data. The divergence between chip stocks and the rest of the market suggests a rotation may be underway, with investors questioning whether AI-related spending can sustain the semiconductor sector's valuation after a 70% year-to-date rally. The next major test comes with Netflix's results after Thursday's close, followed by a wave of Big Tech earnings in the coming weeks. This article is for informational purposes only and does not constitute investment advice.

Jasper Therapeutics Inc. completed its all-stock acquisition of Kira Pharmaceuticals and raised $132 million in a concurrent private placement, creating a combined company with three clinical-stage immunology assets and cash runway through the second half of 2028. "The quality of their science and the deep expertise of their team" drove the decision to merge, Jeet Mahal, president and chief executive officer of Jasper, said in a statement. The combined entity will focus on advancing KP-104, a dual-complement inhibitor for paroxysmal nocturnal hemoglobinuria and renal disorders, alongside briquilimab, an anti-KIT antibody for severe combined immunodeficiency, and KP-701, a preclinical B-cell receptor targeted therapy. The private placement was co-led by Affinity Asset Advisors and Ikarian Capital, with participation from Columbia Threadneedle Investments, Sirenia Capital Management, Balyasny Asset Management, and Mirador Therapeutics, among others. Pro-forma cash is expected to fund operations through multiple clinical milestones, including KP-104 Phase 2 interim data in the fourth quarter of 2026 and an end-of-Phase 2 meeting with the FDA for PNH in the first half of 2027. The deal structure gives pre-merger Jasper equity holders about 6.68% of the combined company's common stock, Kira holders about 49.86%, and PIPE investors about 43.46%, on a fully diluted as-converted basis. Existing Jasper shareholders also received a contingent value right worth $30 million tied to a priority review voucher for briquilimab by December 2028. Kira out-licensed two earlier-stage assets — KP-301 and KP-402 — to Mirador Therapeutics for $12 million upfront plus development and sales milestones, allowing the combined company to concentrate resources on its lead programs. **KP-104 Leads the Pipeline** KP-104, also known as Vensobafusp alfa, is a bifunctional biologic that targets both the alternative and terminal complement pathways simultaneously, a dual mechanism that differentiates it from single-pathway inhibitors such as Alexion's Soliris and Ultomiris. The drug is Phase 2/3 ready and has already generated positive data in treatment-naive PNH patients. The combined company plans to report interim data from Stage 1 of a Phase 2 basket trial in rare renal indications in the fourth quarter of 2026, with updated data in the second quarter of 2027. A new indication for KP-104 will be announced by the end of this year. Briquilimab, a late-stage anti-KIT antibody, is advancing toward a pre-BLA meeting with the FDA for SCID in the first quarter of 2027. The drug blocks stem cell factor from binding to the KIT receptor, inhibiting survival signals for mast cells and hematopoietic stem cells. The company is also evaluating the mast-cell mediated disease landscape and plans to provide an update on clinical development in the second half of 2026. KP-701, a novel dual-acting anti-CD79BxCD32B monoclonal antibody for autoantibody-mediated disorders, is expected to enter Phase 1 testing in the first quarter of 2027, with first-in-human data anticipated in the third quarter. **Cash Runway and Investor Implications** The combined company holds enough capital to reach key value-inflection points without near-term dilution risk, a critical factor for biotech investors evaluating early-stage pipelines. Jasper shares trade on Nasdaq under the ticker JSPR. The company did not disclose post-merger cash balance but said the $132 million private placement, combined with existing cash and the $12 million upfront from the Mirador out-licensing, funds operations through the second half of 2028. This article is for informational purposes only and does not constitute investment advice.

Citi analysts named biopharma stocks a defensive haven in a July 16 research note. The call comes as the NYSE Arca Pharmaceutical Index has outperformed the S&P 500 over the past month, reflecting investor demand for stable earnings and pricing power. The sector's resilient earnings profile and pricing power make it an attractive hedge against broader market volatility, the bank's research team said in a note dated July 16. Citi's analysts highlighted the defensive characteristics of large-cap pharmaceutical companies, which tend to generate consistent cash flows regardless of the economic cycle. The NYSE Arca Pharmaceutical Index has outpaced the broader market as investors seek sectors with less cyclical exposure. The S&P 500 has faced headwinds from uncertainty over interest rates and economic growth, driving capital toward defensive industries. Healthcare has historically been one of the best-performing sectors during periods of market stress, with pharmaceutical companies offering both dividend income and earnings visibility. The call could accelerate capital rotation into healthcare, a sector that has lagged the technology-driven rally for much of the past two years. Biopharma stocks offer a combination of dividend income and earnings visibility that becomes more attractive as macroeconomic uncertainty persists. Citi's endorsement adds institutional credibility to the trade, potentially pushing the NYSE Arca Pharmaceutical Index higher relative to the broader market in the near term. For holders, the Citi note reinforces the case for healthcare as a portfolio hedge against broader market weakness. Investors will watch upcoming earnings reports from major pharmaceutical companies, including Merck and Eli Lilly, for confirmation of the defensive thesis. This article is for informational purposes only and does not constitute investment advice.